FIGURE

Fig. S10

ID

ZDB-FIG-180703-43

Publication

Campbell et al., 2018 - Directing Nanoparticle Biodistribution Through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

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Fig. S10

Gene expression in stab2^ibl2 homozygous mutant embryos. Whole-mount in situ hybridization of stab1 and mrc1 mRNA expression at 56hpf and stab2 mRNA expression at 32hpf and 56hpf in the trunk and tail of stab2^ibl2 homozyogous mutant and sibling control embryos. A reduction in stab2 expression indicating nonsense-mediated decay of the stab2^ibl2 mRNA is observed stab2^ibl2 homozygous, but not sibling control embryos. Expression of stab1 and mrc1 is unchanged indicating normal SEC differentiation.

Expression Data

Genes:	mrc1a stab1 stab2
Fish:	AB/TL stab2^ibl2/ibl2
Anatomical Terms:	post-vent region trunk
Stage Range:	Prim-15 to Long-pec

Expression Detail

Gene	Fish	Conditions	Stage	Anatomy	Assay
mrc1a	AB/TL	control	Long-pec	post-vent region	ISH
mrc1a	AB/TL	control	Long-pec	trunk	ISH
mrc1a	stab2^ibl2/ibl2	control	Long-pec	post-vent region	ISH
mrc1a	stab2^ibl2/ibl2	control	Long-pec	trunk	ISH
stab1	AB/TL	control	Long-pec	post-vent region	ISH
stab1	AB/TL	control	Long-pec	trunk	ISH
stab1	stab2^ibl2/ibl2	control	Long-pec	post-vent region	ISH
stab1	stab2^ibl2/ibl2	control	Long-pec	trunk	ISH
stab2	AB/TL	control	Prim-15	post-vent region	ISH
stab2	AB/TL	control	Prim-15	trunk	ISH

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Antibody Labeling

No data available

Phenotype Data

Fish:	stab2^ibl2/ibl2
Observed In:	post-vent region trunk
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

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