FIGURE

Fig. 2

ID

ZDB-FIG-180622-59

Publication

Singh et al., 2017 - Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling

Other Figures

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Fig. 2

Loss of npy Reduces Daytime Sleep (A) Sequences of WT and mutant zebrafish NPY proteins. The mature peptide is indicated with a red box. Altered amino acids in the mutant are shaded gray. (B–M) npy−/− animals were more active (B and C), and slept less (E and F), than their npy+/+ and npy+/− siblings during the day, due to fewer sleep bouts (H) and longer wake bouts (L). There was no difference in activity (B and D), sleep (E and G), sleep bout number (I) or wake bout length (M) at night, or in sleep bout length during the day (J) or night (K). Mean ± SEM from seven experiments is shown. n, number of animals. ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001 by one-way ANOVA with Holm-Sidak test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	npy^ct811/ct811 (AB/TL) npy^ct811/+ (AB/TL)
Observed In:	circadian sleep/wake cycle, sleep circadian sleep/wake cycle, wakefulness swimming
Stage:	Day 5

Phenotype Detail

Acknowledgments

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