FIGURE
Fig. 8
- ID
- ZDB-FIG-180523-8
- Publication
- Fu et al., 2018 - Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes
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Fig. 8
Secreted Crb2b-sfEX induces apoptosis in cones. Retinal flat-mount preparations double-immunolabeled with anti-Crb2a (green) and the apoptotic marker, anti-active caspase 3 (magenta). (A–A''', B–B''') Cells labeled with anti-active caspase 3 were in the photoreceptor layer, as indicated by anti-Crb2a label. (A–A'') and (B–B'') represent 2D planar views, and (A''') and (B''') include 3D-reconstructed “cut views” (in the xz and xy planes) at the level of the OLM, indicated by the white cross hairs, demonstrating that apoptotic and photoreceptor-specific labels are in the photoreceptor layer. (C–C''') Active caspase 3–labeled photoreceptors were not observed in WT retinas.
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Expression Data
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| Antibody: | |
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| Stage: | Adult |
Expression Detail
Antibody Labeling
Phenotype Data
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| Observed In: | |
| Stage: | Adult |
Phenotype Detail
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Full text @ Invest. Ophthalmol. Vis. Sci.