FIGURE

Fig. 7

ID

ZDB-FIG-180504-7

Publication

Montague et al., 2017 - Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

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Fig. 7

Model for mesendoderm induction in zebrafish.

As described in the main text: (1) vg1 mRNA is inherited from the mother, and is ubiquitous in the early embryo; (2) Vg1 protein is synthesized ubiquitously and retained predominantly in the ER; (3) cyc and sqt are transcribed and translated in the YSL; (4) Cyc and Sqt form heterodimers with Vg1, resulting in Vg1 secretion and cleavage; (5) Cyc-Vg1 and Sqt-Vg1 heterodimers activate the Nodal signaling pathway to induce mesendoderm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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