FIGURE

Fig. 6

ID

ZDB-FIG-180222-23

Publication

Akerberg et al., 2017 - Histone demethylases Kdm6ba and Kdm6bb redundantly promote cardiomyocyte proliferation during zebrafish heart ventricle maturation

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Fig. 6

Bulk cellular H3K27me3 levels transiently decrease in trabeculating cardiomyocytes. (A-F) Confocal microscopy immunofluorescence images of sagittal sections through the heart of 2.5, 3.5, and 5 dpf Tg(kdrl:EGFP) embryos stained with anti-myosin heavy chain (red, MF20, myocardium), anti-EGFP (white, endocardium), and anti-H3K27me3 (green) antibodies. Hoechst-stained nuclei are blue. Zoomed images of the yellow boxed areas (in A, C, and E) are shown in (B, D, and F) with adjacent single channel H3K27me3 and nuclei staining to highlight differences in bulk H3K27me3 levels. Magenta and white arrowheads indicate nuclei of epicardial and endocardial cells, respectively. Yellow and red arrowheads mark H3K27me3-high and H3K27me3-low cardiomyocyte nuclei, respectively. 20 μM and 5 μM (zoom panels) scale bars are shown.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 426(1), Akerberg, A.A., Henner, A., Stewart, S., Stankunas, K., Histone demethylases Kdm6ba and Kdm6bb redundantly promote cardiomyocyte proliferation during zebrafish heart ventricle maturation, 84-96, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.