FIGURE

Fig. 3

ID

ZDB-FIG-180207-2

Publication

Hale et al., 2017 - Shp2-MAPK signalling drives proliferation during zebrafish embryo caudal fin-fold regeneration

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Fig. 3

Formation of wound epidermis and distal blastema in zebrafish embryos lacking functional Shp2. At 2 dpf, the caudal fin folds of zebrafish embryos from a ptpn11a^+/− ptpn11b^−/− incross were amputated and allowed to regenerate. The embryos were fixed at 3 hpa, or the equivalent for uncut controls, and subjected to hybridization using probes specific for mmp9 (A) or junbb (B). Representative images of caudal fin folds of genotyped embryos are shown, and the number of embryos showing similar patterns/total number of embryos analyzed are indicated in the bottom right corner of each image.

Expression Data

Genes:	junbb mmp9
Fish:	ptpn11b^{hu5920/hu5920} (TL) ptpn11a^hu3459/+; ptpn11b^{hu5920/hu5920} (TL) ptpn11a^{hu3459/hu3459}; ptpn11b^{hu5920/hu5920} (TL)
Condition:	amputation: caudal fin
Anatomical Terms:	caudal fin blastema caudal fin regeneration epithelium
Stage:	Day 5

Expression Detail

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay
junbb	ptpn11a^hu3459/+; ptpn11b^{hu5920/hu5920} (TL)	control	Day 5	Not Detected	caudal fin	ISH
junbb	ptpn11a^hu3459/+; ptpn11b^{hu5920/hu5920} (TL)	amputation: caudal fin	Day 5		caudal fin blastema	ISH
junbb	ptpn11a^{hu3459/hu3459}; ptpn11b^{hu5920/hu5920} (TL)	control	Day 5	Not Detected	caudal fin	ISH
junbb	ptpn11a^{hu3459/hu3459}; ptpn11b^{hu5920/hu5920} (TL)	amputation: caudal fin	Day 5		caudal fin blastema	ISH
junbb	ptpn11b^{hu5920/hu5920} (TL)	control	Day 5	Not Detected	caudal fin	ISH
junbb	ptpn11b^{hu5920/hu5920} (TL)	amputation: caudal fin	Day 5		caudal fin blastema	ISH
mmp9	ptpn11a^hu3459/+; ptpn11b^{hu5920/hu5920} (TL)	control	Day 5	Not Detected	caudal fin	ISH
mmp9	ptpn11a^hu3459/+; ptpn11b^{hu5920/hu5920} (TL)	amputation: caudal fin	Day 5		caudal fin regeneration epithelium	ISH
mmp9	ptpn11a^{hu3459/hu3459}; ptpn11b^{hu5920/hu5920} (TL)	control	Day 5	Not Detected	caudal fin	ISH
mmp9	ptpn11a^{hu3459/hu3459}; ptpn11b^{hu5920/hu5920} (TL)	amputation: caudal fin	Day 5		caudal fin regeneration epithelium	ISH

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Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cell. Biol.