FIGURE

Fig. 5

ID

ZDB-FIG-180118-43

Publication

Zabinyakov et al., 2017 - Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology

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Fig. 5

EEG results of two knock-out homozygous aldh7a1 embryos and wild type embryo at 9 dpf. The results represented as number of events (per 300 seconds), duration of each event (seconds) and amplitude (mV) of each event as baseline and on treatment. Each event was considered as a single spike discharge of the EEG recording. Right panel reports events in a knock-out homozygous aldh7a1 embryo, their treatment with 100 μM diazepam and followed by 25 mM pyridoxine treatment. The middle panel shows events in another knock-out homozygous aldh7a1 embryo, their treatment with 100 μM diazepam and followed by 25 mM pyridoxine treatment. The left panel reports events in a wild type on 15 mM pentylenetetrazole to produce spikes and treat them with 100 μM diazepam. Error bars of are standard error of the mean (SEM).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT aldh7a1^{zf2074/zf2074}
Conditions:	chemical treatment: diazepam chemical treatment: diazepam chemical treatment: pentetrazol chemical treatment: diazepam chemical treatment: phenobarbital chemical treatment: phenobarbital
Observed In:	regulation of neuronal action potential
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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