Fig. 1
DRG pioneer axons navigate directly to the DREZ. (A) Images and traced schematics from a 24 hour time-lapse movie starting at 48 hpf in a Tg(ngn1:egfp) embryo showing navigation of the DRG pioneer axon toward the DREZ. Orange box indicates location of DREZ. Arrows denote the growth cone and arrowheads denote location of cell body. Blue process in schematic denotes peripheral axon. (B) Quantification of the distance (y-axis) and time (x-axis) of 4 growth cones as they navigated toward the DREZ. (C) Schematic tracings of 3 pioneer axons as they navigated to the DREZ. Compass shows Dorsal-D, Ventral-V, Anterior-A, Posterior-P. Scale bar, 25 μm. |