FIGURE

Fig. 4

ID

ZDB-FIG-180103-47

Publication

Iribarne et al., 2017 - Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish

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Fig. 4

The gosh mutant genetically interacts with the els mutant.

(a) Western blot of wild-type and gosh mutant heads with anti-Pde6c antibody. A band of approximately 100 kDa was detected in wild type animals, but disappeared in the gosh mutant. Histone H3 is as a loading control. (b) Semi-quantitative PCR with different numbers of cycles (20, 30 or 40) indicates that mRNA levels are similar between wild-type zebrafish and the gosh mutant. (c) Labeling of els^+/+;gosh^+/+, els^−/−;gosh^+/+, and els^−/−;gosh^+/− retinas with the zpr1 antibody. The ratio of zpr1-postive area relative to the total retinal area is significantly decreased in els^−/−;gosh^+/− retinas compared to els^−/−;gosh^+/+ retinas. ANOVA was significantly different (p< 0.000016) by t-test with a Bonferroni correction post-hoc (*p < 0.05; **p < 0.01; ***p < 0.001).

Expression Data

Antibody:	zpr-1
Fish:	WT pde6c^rw76a/rw76a pde6c^rw76a/rw76a; aipl2^oki6/+
Anatomical Term:	retina
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pde6c^rw76a/rw76a pde6c^rw76a/rw76a; aipl2^oki6/+
Observed In:	retina photoreceptor cell
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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