FIGURE

Fig. S5

ID

ZDB-FIG-171201-2

Publication

Sharma et al., 2016 - ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions

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Fig. S5

Pronephric structural alterations in ELMO1 crispants could be rescued completely via ELMO1 mRNA.

As compared to the zebrafish pronephros at 48 hpf in controls, Co. CRISPR + mRNA., A., ELMO1 over-expression B., has no detrimental effects on the zebrafish pronephros. C. ELMO1 crispants display detrimental effects on the zebrafish pronephric structure, with an enlarged glomerulus (white arrow head) and highly shortened pronephric neck (white asterix). However, D., overexpression of ELMO1 in ELMO1 crispants significantly rescues pronephric phenotype. E., F. the altered structure in ELMO1 crispants and their subsequent rescue with ELMO1 overexpression is quantified in n=40 embryos, for each condition. The white line in D., indicates a scale bar of 200 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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