FIGURE

Fig. 4

ID

ZDB-FIG-170824-7

Publication

Roberson et al., 2017 - Convergence of signaling pathways underlying habenular formation and axonal outgrowth

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Fig. 4

Specification of dbx1b⁺ dHb progenitors requires Shh signaling upstream of or parallel to Wnt signaling. At 36 hpf, (A,A′) cxcr4b and (B-C′) dbx1b transcripts are found in the developing dHb of (A,B,C) WT embryos, but not in the corresponding diencephalic region of (A′,B′,C′) smo mutants (arrowheads). Expression of (D-E′) shha and (F-G′) ptch1 is comparable in (D,E,F,G) WT embryos and (D′,E′,F′,G′) wls mutants. Sibling WT and homozygous wls mutant embryos are distinguished by the presence or absence of wls transcripts (Kuan et al., 2015). Dorsal (A-B′,D,D′,F,F′) and lateral (C,C′,E,E′,G,G′) views are shown. Scale bars: 30 µm.

Expression Data

Genes:	cxcr4b dbx1b ptch1 shha wls
Fish:	WT smo^{hi1640Tg/hi1640Tg} wls^c186/c186
Anatomical Terms:	diencephalon dorsal habenular nucleus zona limitans intrathalamica
Stage Range:	Prim-5 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smo^{hi1640Tg/hi1640Tg} wls^c186/c186
Observed In:	diencephalon dorsal habenular nucleus
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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