FIGURE

Fig. 9 S1

ID

ZDB-FIG-170620-20

Publication

Erickson et al., 2017 - Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

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Fig. 9 S1

Tmc2b-GFP can restore basal MET channel activity to tmc2b^sa8817 mutants.

(A–D) Representative, merged GFP-DIC images of neuromast hair bundles (left) and FM 4–64 label (right) in 6 dpf non-transgenic, wild-type siblings (A), non-transgenic, tmc2b^sa8817 mutants (B), Tg(myo6b:tmc2b-GFP), wild-type siblings (C), and Tg(myo6b:tmc2b-GFP), tmc2b^sa8817 mutants (D). (E) Quantification of FM 4–64 fluorescence intensity per NM for the genotypes shown in A-D. Non-transgenic siblings: n = 3 larvae, 5 NM. Non-transgenic tmc2b^sa8817: n = 3 larvae, 5 NM. Tg(tmc2b-GFP) siblings: n = 10 larvae, 28 NM. Tg(tmc2b-GFP) / tmc2b^sa8817: n = 2 larvae, 6 NM. Error bars are the mean ± SD. ns = not significant. Asterisks indicate p<0.0001 by one-way ANOVA with Bonferroni's multiple comparison test. Scale bars = 5 µm in A-D.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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