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Fig. S1

ID

ZDB-FIG-170505-25

Publication

Torraca et al., 2017 - The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme

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Fig. S1

Function of il1b on trunk granulomas.

A-B. Induction of the proangiogenetic inflammatory mediator il1b at the trunk granuloma. The large granuloma forming in the trunk contains a high number of il1b-expressing cells, predominantly consisting of infected cells. Confocal images were acquired at 5 dpi from infected Tg(il1b:eGFP-F) larvae. Scale bars: A: 50 μm; B: 5 μm. C-D. Despite being largely induced in infected cells during trunk granuloma formation, and notably suppressed by cxcr4b mutation, depletion of il1b does not recapitulate cxcr4b phenotype in granuloma vascularisation, since il1b morphants could still develop normally vascularise granulomas. Data were obtained and analysed as in Figure 3I-J (2 replicates, cumulated).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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