FIGURE

Fig. 4

ID

ZDB-FIG-170426-16

Publication

Zhang et al., 2017 - Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis

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Fig. 4

Akt2 mutants exhibit delayed fin generation. (A) At 21 dpf, MZakt2^−/− mutants displayed shorter protrusions, aberrant extension, and reduced number of segments of fin rays in pectoral fin, dorsal fin, canal fin, and caudal fin compared with their wildtype siblings. (B–C) At adult stage (4 months), MZakt2^−/− mutants displayed delayed fin generation. (D) At 21 dpf, the joint between the muscle and dorsal fin or anal fin, and the connection between the caudal fin and the spine were normal in MZakt2^−/− mutants compared with their wildtype siblings, as revealed by Alcian blue staining. (E) Alizarin red-staining of caudal fin from wild-type and homozygous adult zebrafish. Scale bars are shown in the pictures.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	akt2^{ihb504/ihb504} akt2^{ihb505/ihb505}
Observed In:	anal fin development anal fin morphogenesis caudal fin development caudal fin morphogenesis dorsal fin development dorsal fin morphogenesis pectoral fin development pectoral fin morphogenesis
Stage Range:	Days 21-29 to Adult

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 143, Zhang, D., Wang, J., Zhou, C., Xiao, W., Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis, 42-52, Copyright (2017) with permission from Elsevier. Full text @ Mech. Dev.