FIGURE

Fig. 2

ID

ZDB-FIG-170424-43

Publication

Smith et al., 2017 - A novel early onset phenotype in a zebrafish model of merosin deficient congenital muscular dystrophy

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Fig. 2

Muscle fiber detachment of caf mutants can be observed with birefringence.

Under plane polarized light, muscle from WT siblings (A) appears uniformly bright and white, consistent with normal muscle organization. In contrast, Caf mutants (B-F_ can be identified as having stochastic patterns of muscle degeneration and detachment with birefringence as early as 2 dpf. This is seen in the muscle compartment as dim white areas (thinned or atrophied fibers) and black spots (presumed areas of muscle fiber detachment). Of note, genotype for all depicted animals was confirmed by Sanger sequencing. Bars represent mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lama2^{teg15a/teg15a}
Observed In:	muscle somite somite muscle cell trunk musculature
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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