FIGURE

Fig. 5

ID

ZDB-FIG-170210-5

Publication

Wang et al., 2016 - The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis

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Fig. 5

Maeg regulates ISV tip cell behaviors. A. Still images from in vivo time-lapse imaging analysis of WT and maeg^−/−Tg(fli1a:nEGFP) embryos. Time (hpf) is noted in the top. Nuclei of ISVs are numbered. B. Percentage of ISVs with tip cell division in control embryos and maeg^−/− embryos. Student’s t-test; ***,P<0.001. C. Migration speed of ISV tip cells. Mann Whitney U-test; ***,P<0.001. D. Still images from in vivo time-lapse imaging analysis of ISV tip cell filopodia in Tg(kdrl:EGFP) embryos. Time (hpf) is noted in the bottom. Red arrowheads indicate filopodia extensions. E. Confocal imaging analysis of ISV tip cell filopodia in Tg(kdrl:EGFP) embryos with HD detection setting. Red arrowheads indicate filopodia extensions. F. ISV tip cell filopodia number in per ISVs. One-Way ANOVA; ***, P<0.001.

Expression Data

Gene:	EGFP
Fish:	s843Tg y7Tg egfl6^zf774/zf774; s843Tg egfl6^zf774/zf774; y7Tg
Anatomical Terms:	endothelial cell nucleus endothelial tip cell filopodium intersegmental vessel intersegmental vessel endothelial cell intersegmental vessel endothelial tip cell trunk vasculature
Stage Range:	26+ somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	egfl6^zf774/zf774; s843Tg egfl6^zf774/zf774; y7Tg
Observed In:	endothelial tip cell cell division endothelial tip cell cell migration involved in sprouting angiogenesis endothelial tip cell filopodium intersegmental vessel endothelial tip cell sprouting angiogenesis
Stage Range:	26+ somites to Prim-15

Phenotype Detail

Acknowledgments

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