Fig. 8
- ID
- ZDB-FIG-161019-11
- Publication
- Ellis et al., 2016 - Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development
- Other Figures
- All Figure Page
- Back to All Figure Page
Morpholino knock-down of the aryl hydrocarbon receptor rescues some but not all effects of PhN treatment. Tg(fli1:eGFP) embryos were injected with morpholinos demonstrated to interfere with the expression of AhR2, thereby protecting them from PAH-toxicity, or control morpholinos, and were then exposed to 10 µM PhN from 24 to 48 hpf. (A) Control morphants exhibit typical PAH toxicity effects (tail curvature, necrosis, pericardial and yolk-sac edema), as well as disrupted angiogenesis, loss of pigmentation, and craniofacial defects; (B) Ahr2 morphants exhibit reduced pericardial and yolk-sac edema, but still exhibit loss of pigmentation, craniofacial defects; and (C) disrupted angiogenesis. |