FIGURE

Fig. 1

ID

ZDB-FIG-160929-1

Publication

Park et al., 2016 - Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish

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Fig. 1

Loss of ewsa promotes tumorigenesis.

Total numbers of fish for each genotypes are: ewsa^w/w;tp53^w/w (n = 41), ewsa^w/m;tp53^w/w (n = 135), ewsa^m/m;tp53^w/w (n = 21), ewsa^w/w;tp53^w/m (n = 28), ewsa^w/m;tp53^w/m (n = 46), ewsa^m/m;tp53^w/m (n = 39), ewsa^w/w;tp53^m/m (n = 48), ewsa^w/m;tp53^m/m (n = 12), ewsa^m/m;tp53^m/m (n = 19). (A) Representative images of zebrafish. In images of ewsa and tp53mutants, tumors are indicated with an arrow (>). Scale bar: 1cm. (B) Tumor incidence is higher in ewsa^w/m;tp53^w/m and ewsa^m/m;tp53^w/m compared to ewsa^w/w;tp53^w/m; and in ewsa^w/m;tp53^m/m and ewsa^m/m;tp53^m/m compared to ewsa^w/w;tp53^m/m zebrafish. (C) Average age at tumor onset is lower in ewsa^w/m;tp53^w/m and ewsa^m/m;tp53^tp53w/m compared to ewsa^w/w;tp53^w/m; and in ewsa^w/m;tp53^m/m and ewsa^m/m;tp53^m/m compared to ewsa^w/w;tp53^m/m zebrafish. (D) Representative images of H&E staining of tumors observed in zebrafish. MPNST-like: malignant peripheral nerve sheath tumor-like; SRBCT: small round blue cell tumor.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1 tp53^zdf1/+ tp53^zdf1/+; ewsr1a^{zm00260171Tg/+} tp53^zdf1/+; ewsr1a^{zm00260171Tg/zm00260171Tg} tp53^zdf1/zdf1; ewsr1a^{zm00260171Tg/+} tp53^zdf1/zdf1; ewsr1a^{zm00260171Tg/zm00260171Tg}
Observed In:	whole organism whole organism neoplasm
Stage:	Adult

Phenotype Detail

Acknowledgments

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