FIGURE

Fig. 10

ID

ZDB-FIG-160602-20

Publication

McCarthy et al., 2016 - Pdgfra and Pdgfrb genetically interact during craniofacial development

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Fig. 10

Neither cell death nor proliferation is significantly affected in the maxillary domain of pdgfra;pdgfrb mutants. A-D: The 24 hpf fli1:EGFP zebrafish embryo with corresponding genotypes listed left of panels, stained for active caspase 3 (A and B in red; A′ and B′ in gray), and phospho-histone H3 (pHH3) in (C,D). Anterior is to the left. B–B′: pdgfra-/-;pdgfrb-/- embryos show increased total cell death at 24 hpf, but not in the maxillary domain crest (arrowheads show cell death above the eye, maxillary domain is outlined in panel A). E: Bar chart representing either total (gray bars) or maxillary domain (light bars) number of active caspase 3-positive or pHH3-positive fli1:EGFP cells in corresponding genotypes (Students t-test, P ≤ 0.05). Scale bar = 100 µm.

Expression Data

Gene:	EGFP
Fish:	pdgfra^b1059/b1059; y1Tg pdgfra^b1059/b1059; pdgfrb^um148/um148; y1Tg
Anatomical Term:	chondrocranium cartilage cranial neural crest cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdgfra^b1059/b1059; y1Tg pdgfra^b1059/b1059; pdgfrb^um148/um148; y1Tg
Observed In:	chondrocranium cartilage apoptotic process chondrocranium cartilage cell population proliferation
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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