FIGURE

Fig. 1

ID

ZDB-FIG-160525-25

Publication

Zhao et al., 2016 - An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

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Fig. 1

Generation of a zebrafish grk2 null mutation

A. Phylogenic tree showing the relationship of the various vertebrate Grk genes and the Drosophila gprk gene.

B. Schematic representation of the exon 1 nucleotide sequence of zebrafish grk2 gene targeted by the ZFN.

C. Schematic representation of the zebrafish Grk2 protein domains and the truncated peptide predicted to be encoded by the grk2ⁱ²⁸³ mutant allele.

D. Homozygous grk2ⁱ²⁸³ mutant at 4dpf compared to wild type (WT) sibling (N = 80). Arrows indicate the position of swim bladder. Scale bar, 1 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	grk3^i283/i283
Observed In:	swim bladder development
Stage:	Day 4

Phenotype Detail

Acknowledgments

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