FIGURE

Fig. 7

ID

ZDB-FIG-160512-16

Publication

Zhang et al., 2016 - Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration

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Fig. 7

Müller glia remained in a dedifferentiated state after GCV treatment. (A) Green fluorescent protein and BrdU immunofluorescence showing the presence of strong GFP+ Müller glia at the injury site in GCV-treated retina at 8 and 12 dpi. Only very weakly GFP-expressing cells were found in the PBS-treated control. Tg(1016tuba1a:GFP) fish were given a pulse of BrdU 3 hours before they were killed at 8 or 12 dpi. (B) qPCR analysis of the expression of gfp, ascl1a, hbegfa, and socs3a in PBS- or GCV-treated retinas at 12 dpi. (C) qPCR analysis of the same genes in GCV-treated retinas at 0, 4, 8, and 12 dpi. n = 4 for each group. **P < 0.01; ***P < 0.001 compared to PBS control. Scale bars: 100 µm. The asterisks mark the injury site (needle poke).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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