FIGURE

Fig. 3

ID

ZDB-FIG-160426-4

Publication

Berg et al., 2016 - Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

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Fig. 3

snapc1b Mutant Macrophages Fail to Participate in Granuloma Formation

(A) Confocal images of granulomas in the hindbrain ventricle of snapc1b mutant larvae and WT siblings with green fluorescent macrophages at 2 dpi with 100 red fluorescent Mm. Scale bar, 60 µm.

(B) Tracks of macrophage movement following granuloma formation in snapc1b mutant larvae and WT siblings shown in (A). Tracks are coded for speed. Tracks created by vacuolated macrophages are indicated with an asterisk.

(C and D) Speed (C) and displacement (D) of snapc1b mutant and WT sibling macrophages in (A and B). Statistical significance was assessed using one-way ANOVA with Sidak’s post-test.

Expression Data

Gene:	YFP
Fish:	w200Tg (AB) snapc1b^fh111/fh111; w200Tg (AB)
Condition:	bacterial treatment by injection: Mycobacterium marinum
Anatomical Term:	macrophage
Stage Range:	Day 5 to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	snapc1b^fh111/fh111; w200Tg (AB)
Condition:	bacterial treatment by injection: Mycobacterium marinum
Observed In:	granuloma formation macrophage granuloma formation macrophage myeloid leukocyte migration
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

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Reprinted from Cell, 165, Berg, R.D., Levitte, S., O'Sullivan, M.P., O'Leary, S.M., Cambier, C.J., Cameron, J., Takaki, K.K., Moens, C.B., Tobin, D.M., Keane, J., Ramakrishnan, L., Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration, 139-152, Copyright (2016) with permission from Elsevier. Full text @ Cell