FIGURE

Fig. 1

ID

ZDB-FIG-150915-41

Publication

Antunes et al., 2015 - Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway

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Fig. 1

Early cell death of RP mutant cells requires p53.

A) Acridine orange staining allowing visualization of dying cells in wild type or rpS7 mutants at 1 dpf that are uninjected, injected with the p53 MO, or injected with the missense MO. Size bar = 0.25mm. B) Quantification of (A). **p<0.01. C) Acridine orange staining of a rpS7 mutant is observed predominantly in the brain region (arrowhead) or distributed over the surface of the tail (white boxes). D) Scoring results from o-dianisidine staining allowing visualization of hemoglobin-expressing cells in clutches of either 111 embryos (+mis MO) or 177 embryos (+p53 MO) from an rpS7 pairing.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rps7^{hi1034bTg/hi1034bTg} rps7^{hi1034bTg/hi1034bTg} + MO4-tp53
Knockdown Reagent:	MO4-tp53
Observed In:	apoptotic process brain apoptotic process caudal fin apoptotic process hemopoiesis nucleate erythrocyte
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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