FIGURE

Fig. 5

ID

ZDB-FIG-150518-25

Publication

Kim et al., 2015 - A Post-Developmental Genetic Screen for Zebrafish Models of Inherited Liver Disease

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Fig. 5

Histological phenotypes.

On the left panel, H & E (top), DAPI (middle) and oil red oil (ORO, bottom) stained zebrafish livers at 8 dpf are shown. Wild-type control (A,F,K), and mutants (B-E, G-J, L-O) are shown. (B) shows and example of microvesicles in hepatocytes, (C) depicts a liver with swollen hepatocytes, (D) shows a liver with accumulation of large vesicles, and prenecrotic hepatocytes (asterisk), while (E) shows hepatic lysis. The black arrow in (E) points to a nucleus with nuclear membrane and the red arrow points to a condensed nucleus without nuclear membrane. The yellow arrowheads in (J) indicate granulated nuclei. g = gut. Scale bar = 100 µm (A-E) and 50 µm (F-O). n = 9/9 per control and each mutant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	etfa^vu463/vu463 (AB) naxe^{muz108/muz108} (AB) unm_muz104^{muz104/muz104} (AB) vmp1^{muz110/muz110} (AB)
Observed In:	hepatocyte hepatocyte microvesicle hepatocyte nucleus hepatocyte vesicle
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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