FIGURE

Fig. 6

ID

ZDB-FIG-150401-11

Publication

Radosevic et al., 2014 - The Role of her4 in Inner Ear Development and Its Relationship with Proneural Genes and Notch Signalling

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Fig. 6

Blockade of her4 has no increase on atoh1b and atoh1a expression.

(A–B) Dorsal views of 14 hpf control (A) and her4-MO injected (B) embryos stained by in situ hybridization for atoh1b. atoh1b expression is not affected in the prosensory domains in her4-MO injected embryos. (C–D) Dorsal views of 24 hpf control (C) and her4-MO injected (D) embryos stained by in situ hybridization for atoh1a. atoh1a expression decreases in her4-MO injected embryos. (E–F′) Transversal sections anterior (E, F) and posterior sections (E′, F′) of 28 hpf control (E, E′) and her4-MO injected (F, F′) embryos stained by in situ hybridization for atoh1a. atoh1a expression is as wild-type in her4-MO injected embryos. Dashed circles delineate otic vesicles. All images are at same magnification. Scale bar: 25 µm.

Expression Data

Genes:	atoh1a atoh1b
Fish:	AB AB + MO2-her4
Knockdown Reagent:	MO2-her4
Anatomical Terms:	otic placode otic vesicle
Stage Range:	10-13 somites to Prim-5

Expression Detail

Gene	Fish	Conditions	Stage	Anatomy	Assay
atoh1a	AB	standard conditions	Prim-5	otic vesicle	ISH
atoh1a	AB + MO2-her4	standard conditions	Prim-5	otic vesicle	ISH
atoh1b	AB	standard conditions	10-13 somites	otic placode	ISH
atoh1b	AB + MO2-her4	standard conditions	10-13 somites	otic placode	ISH

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Antibody Labeling

No data available

Phenotype Data

Phenotype Detail

Acknowledgments

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