FIGURE

Fig. 3

ID

ZDB-FIG-150330-7

Publication

Marín-Juez et al., 2015 - GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish

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Fig. 3

Morphant phenotype caused by abrogation of glut2 can be rescued with full-length zebrafish glut2 and rat GLUT2 mRNA. Phenotype of embryos injected with a control morpholino (Con MO) at 48 hpf (A), ATG morpholino (ATG MO) at 48 hpf (B) and splice morpholino (Splice MO) at 48 hpf (C). Rescue of overall morphant phenotype at 48 hpf by co-injection of ATG MO with rat GLUT2 mRNA (rGLUT2; D) and of Splice MO with zebrafish glut2 (zfGLUT2; E). (F–J) Shows higher magnification images of the cephalic region of Con MO (F), ATG MO (G), Splice MO (H), rescued ATG morphants (I), and rescued splice morphants (J). The hindbrain region (outlined by black dotted line) is affected in the morphants (G and H), while brain development in rescued embryos (I and J) is similar to that observed in control embryos (F).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cereb. Blood Flow Metab.