FIGURE

Fig. 7

ID

ZDB-FIG-150224-18

Publication

Kjaer-Sorensen et al., 2014 - Papp-a2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos

Other Figures

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Fig. 7

papp-a2-knockdown reduces Notch signaling activity in the CNS. (A) Representative images of control and papp-a2-knockdown Notch activity reporter embryos [Tg(Tp1bglob:eGFP)^um13] showing the range of Notch reporter fluorescence levels. Embryos were grouped according to fluorescence levels ranging from 1 (very low Notch signaling activity) to 4 (maximum Notch signaling activity). (B) Plot showing the percentage of embryos at each fluorescence level in control and knockdown embryos. n = 20 (cMO), 24 (e1i1), 30 (ATG), 14 (i3e4). (C) her6 whole-mount in situ hybridization of 24 hpf embryos. Numbers indicate fractions of embryos displaying the depicted phenotype. hb, hindbrain; mb, midbrain.

Expression Data

Gene:	her6
Fish:	WT WT + MO1-pappa2 + MO4-tp53 WT + MO2-pappa2 + MO4-tp53 WT + MO3-pappa2 + MO4-tp53
Knockdown Reagents:	MO1-pappa2 MO2-pappa2 MO3-pappa2 MO4-tp53
Anatomical Terms:	hindbrain midbrain
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	um13Tg + MO1-pappa2 + MO4-tp53 um13Tg + MO2-pappa2 + MO4-tp53 um13Tg + MO3-pappa2 + MO4-tp53
Knockdown Reagents:	MO1-pappa2 MO2-pappa2 MO3-pappa2 MO4-tp53
Observed In:	Notch signaling pathway
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.