FIGURE

Fig. 1

ID

ZDB-FIG-150127-10

Publication

Hüsken et al., 2014 - Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons

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Fig. 1

tcf7l2 Is Required for the Establishment of Habenular Asymmetry

(A and A′) Dorsal views of 4 dpf (days postfertilization) embryos, with anterior to the left, labeled with a cocktail of markers that reveal habenular asymmetry (kctd12.1) and position of liver (sepB) and pancreas (trypsin). The arrowheads indicate normal (A) and increased (A′) kctd12.1 expression in the right habenula.

(B and B′) Dorsal views of the habenulae with anterior to the top showing symmetric kctd12.1 expression in a wild-type fry (B) and a tcf7l2 mutant (B′).

(C) Diagram of intron/exon structure for tcf7l2 showing the tcf7l2^exl [26], tcf7l2^u763, and tcf7l2^u754 alleles. Arrows point to mutation sites. The inset shows dorsal views, with anterior to the top, of 4 dpf wild-type (wt) and tcf7l2^u754/u754 mutant embryos stained for Tcf7l2 (green) and Sytox orange (gray).

Hb, habenula; l, liver; p, pancreas. See also Figure S1.

Expression Data

Gene:	kctd12.2
Antibody:	Ab1-tcf7l2
Fish:	WT tcf7l2^u754/u754 tcf7l2^u763/u763
Anatomical Term:	habenula
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tcf7l2^u754/u754 tcf7l2^u763/u763 tcf7l2^zf55/zf55
Observed In:	habenula determination of left/right asymmetry in diencephalon
Stage:	Day 4

Phenotype Detail

Acknowledgments

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