FIGURE

Fig. S2

ID

ZDB-FIG-140807-21

Publication

Zhang et al., 2014 - Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish

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Fig. S2

Exocrine pancreas-specific downregulation or upregulation of ctr1l, 69 ctrb1, ela2l, try and tryl resulted from overexpression or knockdown of bach1b 70 and nrf2a, revealed by in situ hybridization. Representative images of in situ 71 hybridization staining show that upregulation or downregulation of ctr1l, ctrb1, ela2l, 72 try and tryl specifically in the zebrafish exocrine pancreas. Downregulation of ctr1l, 73 ctrb1, ela2l, try and tryl specifically in the exocrine pancreas resulted from bach1b 74 overexpression and nrf2a knockdown, and upregulation of ctr1l, ctrb1, ela2l, try and 75 tryl specifically in the exocrine pancreas resulted from nrf2a overexpression and 76 bach1b knockdown. Dorsal view, anterior to left. All larvae were 84 HPF.

Expression Data

Genes:	ctrb.1 ctrl ela2l prss1 prss59.1
Fish:	WT WT + MO1-bach1b WT + MO1-nfe2l2a
Knockdown Reagents:	MO1-bach1b MO1-nfe2l2a
Anatomical Term:	exocrine pancreas
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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