FIGURE

Fig. 3

ID

ZDB-FIG-140326-10

Publication

Lawson et al., 2001 - Notch signaling is required for arterial-venous differentiation during embryonic vascular development

Other Figures

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Fig. 3

In situ hybridization of artery markers in 30-somite stage mib^ta52b mutant and wild-type sibling embryos. (A) In wild-type siblings, ephrinB2 expression is apparent in the DA (red arrowheads in A-J). (B) In mib^ta52b mutant embryos this expression is absent. (C) In wild-type sibling embryos notch3 is expressed within the DA. (D) In mib^ta52b mutant embryos notch3 expression is absent from both vascular and non-vascular tissues. (E) In wild-type sibling embryos grl is expressed specifically in the DA. (F) In mibta52b mutant embryos the expression of grl is not affected. (G) In wildtype sibling embryos deltaC is expressed within the DA. (H) In mib^ta52b mutant embryos expression of deltaC within the DA is decreased in approximately half of the mutant embryos. Excess neuronal expression is apparent (black arrow). (I) In wild-type siblings the T-box transcription factor tbx20 is expressed normally within the roof of the DA. (J) In mib^ta52b mutant embryos this expression is normal. Scale bar (A-J) 100 μm.

Expression Data

Genes:	dlc efnb2a hey2 notch3 tbx20
Fish:	WT mib1^ta52b/ta52b
Anatomical Terms:	dorsal aorta dorsal aorta dorsal side neural tube pronephric duct trunk neuron
Stage:	26+ somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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