FIGURE

Fig. 7

ID

ZDB-FIG-140224-24

Publication

Mawdsley et al., 2004 - The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish

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Fig. 7

Failure to form a lumen in the neural tube of Neogenin morphants. (a) Oblique transverse section through the telencephalon towards the ventral diencephalon stained with hematoxylin and eosin demonstrated that the diencephalic ventricle (v) was formed in the control by 24 hpf. (b) Equivalent section from a Neogenin morphant where no ventricle was formed. (c) The lumen (lu) of the rostral neural tube was apparent in control embryos at 24 hpf. (d) The lumen was absent in the rostral neural tube of morphants. Cells in the bilateral columns of neuroepithelium were fewer and poorly organized in Neogenin morphants (b and d) compared to those in control embryos (a and c). Some cells had delaminated from the neuroepithelium in the morphants and were ectopically positioned in the region where the lumen would normally have formed (b and d: arrows). ml, midline.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-neo1a
Knockdown Reagent:	MO2-neo1a
Observed In:	diencephalon neural tube neural tube development neuroepithelial cell third ventricle
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 269(1), Mawdsley, D.J., Cooper, H.M., Hogan, B.M., Cody, S.H., Lieschke, G.J., and Heath, J.K., The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish, 302-315, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.