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Fig. S11

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ZDB-FIG-131218-12

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Sittaramane et al., 2013 - The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function

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Fig. S11

Aberrant chemokine gene expression in putative detour mutants
(A-D) Dorsal views of the hindbrain region, with anterior to left, in 7-somite stage embryos obtained from a detour te370a/+ incross, processed for in situ hybridization with cxcr7b (A,B) or cxcl12a (C,D). Whereas most embryos (A,C) showed normal expression of these genes in the hindbrain and sensory neurons (arrowheads), some (B,D) exhibited defects (arrowheads). However, sequencing of the gli1 locus that is mutated in the dtr te370a allele did not show linkage between the defective phenotype and the dtr-/- genotype. Nonetheless, it remains formally possible that inefficient migration of FBM neurons in detour mutants results from reduced chemokine signaling.

Expression Data

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Antibody Labeling

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Reprinted from Developmental Biology, 382(2), Sittaramane, V., Pan, X., Glasco, D.M., Huang, P., Gurung, S., Bock, A., Li, S., Wang, H., Kawakami, K., Matise, M.P., and Chandrasekhar, A., The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function, 400-412, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.