FIGURE

Fig. 6

ID

ZDB-FIG-130814-11

Publication

Reimer et al., 2013 - Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration

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Fig. 6

Early Disruption of Dopamine Signaling Has Long-Lasting Consequences for Motor Neuron Numbers and Swimming Behavior (A) Motor neuron numbers (lateral trunk views) are significantly reduced at 9 dpf by exposure to 10 μM L-745870 from 24 to 72 hpf (Kruskal-Wallis p = 0.0102 with Dunn’s multiple comparison, p < 0.05, p < 0.0001). Scale bar, 25 μm. (B and C) Incubation of embryos from 1 to 3 dpf decreases (B) the frequency of a startle response after touch at 4 dpf and (C) the total distance moved and high mobility frequency at 9 dpl (p < 0.01; p < 0.0001). Error bars represent SEM. See also Figure S5.

Expression Data

Gene:	GFP
Fish:	ml2Tg
Condition:	chemical treatment: drug
Anatomical Term:	spinal cord motor neuron
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 25(5), Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y.C., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T., and Becker, C.G., Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration, 478-491, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell