FIGURE

Fig. 6

ID

ZDB-FIG-130220-27

Publication

Henriques et al., 2013 - Telomerase is required for zebrafish lifespan

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Fig. 6

Elimination of tp53 function partially rescues tert^-/- degeneration in proliferative tissues.

tert^-/-tp53^-/- show increased proliferation and apoptosis in both testes (Ac, d and e, f) and gut (Bc, d and e, f), as compared to tert^-/- alone. In the testis, dashed outline represents spermatogenic zone, uniform outline proliferative zone of maturing spermatocytes and L the lumen where mature sperm is located. Elimination of tp53 function partially rescues mature sperm numbers (Aa, b) but completely rescues gut villi length (Ba, b). DNA damage as assessed by 53BP1 is maintained in tert^-/-tp53^-/- testes (Ag and h) and decreased in the gut (Bg and h), as compared to tert^-/-. N≥3. Data are represented as mean +/- SEM. Scale bar = 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tert^{hu3430/hu3430}; tp53^zdf1/zdf1
Observed In:	cell division male organism intestinal villus spermatogonial cell division testis testis sperm whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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