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Fig. 3

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ZDB-FIG-120720-84

Publication

Zeng et al., 2012 - The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism

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Fig. 3

Bmp4 and Shha are downregulated in the gut of miR-145 overexpressing embryos. Overexpression of miR-145 using a miR-145 mimic leads to decreased bmp4 as seen in whole-mount (A, B) and longitudinal section (E, F), and to decreased expression of shha as seen whole-mount (C, D) and in cross section (G, H). (I) Quantification of expression changes in miR-145 mimic shows strong down-regulation of bmp4 and shha but not ihha levels in miR-145 mimic injected embryos. Significance was determined by a Student′s t-test (p<0.01). The scale bar for A–D is shown in panel D, and the scale bar for E–H is in panel H.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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Acknowledgments

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Reprinted from Developmental Biology, 367(2), Zeng, L., and Childs, S.J., The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism, 178-186, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.