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Fig. 3

ID

ZDB-FIG-120720-84

Publication

Zeng et al., 2012 - The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism

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Fig. 3

Bmp4 and Shha are downregulated in the gut of miR-145 overexpressing embryos. Overexpression of miR-145 using a miR-145 mimic leads to decreased bmp4 as seen in whole-mount (A, B) and longitudinal section (E, F), and to decreased expression of shha as seen whole-mount (C, D) and in cross section (G, H). (I) Quantification of expression changes in miR-145 mimic shows strong down-regulation of bmp4 and shha but not ihha levels in miR-145 mimic injected embryos. Significance was determined by a Student′s t-test (p<0.01). The scale bar for A–D is shown in panel D, and the scale bar for E–H is in panel H.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 367(2), Zeng, L., and Childs, S.J., The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism, 178-186, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.