FIGURE

Fig. S2

ID

ZDB-FIG-111128-67

Publication

Zuniga et al., 2011 - Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton

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Fig. S2

CNCC death and skeletal loss in severely affected UAS:Bmp4 embryos. (A,B) Ventral views of 5 dpf whole-mount skeletons in hsp70I:Gal4 control (A) and severely affected UAS:Bmp4 larvae (B). Presumptive high levels of Bmp4 misexpression resulted in reductions of most of the craniofacial skeleton, including ventral mandibular (M) and hyoid (Ch) elements denoted by arrows in (A). (C,D) Confocal projections of control fli1a:GFP (n=3) and UAS:Bmp4; fli1a:GFP (n=7) embryos stained with Lysotracker Red to mark dying cells at 36 hpf. fli1a:GFP (green) marks CNCCs of the pharyngeal arches. Increased numbers of Lysotracker-positive cells were observed in UAS:Bmp4 embryos, and colocalization with fli1a:GFP showed death in both pharyngeal CNCCs and epithelial cells. First and second arch are labeled in control (C); asterisks mark the oral epithelia.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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