FIGURE

Fig. 8

ID

ZDB-FIG-111028-9

Publication

Hale et al., 2011 - Netrin Signaling Breaks the Equivalence between Two Identified Zebrafish Motoneurons Revealing a New Role of Intermediate Targets

Other Figures

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Fig. 8

Netrins are unnecessary for CaP axons to extend to intermediate targets.

Projected confocal stacks of GFP-expressing motor axons in living Tg(mnx1:GFP) embryos injected with various MOs. A–C. In standard control MO-injected embryos CaP axons extend to the second intermediate target by 24 hpf (A), the third intermediate target by 30 hpf (B), and by 36 hpf have extended past the third intermediate target and wrap around the ventral aspect of the myotome (C). In ntn1a SBMO (D–F), ntn1b SBMO (G–I), and ntn2 SBMO (J–L) injected embryos the time course of CaP axon outgrowth was the same as in controls (A–C). Scale bar = 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ml2Tg + MO1-ntn2 ml2Tg + MO2-ntn1a ml2Tg + MO3-ntn1b
Knockdown Reagents:	MO1-ntn2 MO2-ntn1a MO3-ntn1b
Observed In:	axon extension
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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