FIGURE

Fig. 5

ID

ZDB-FIG-111025-23

Publication

Madelaine et al., 2011 - Partially redundant proneural function reveals the importance of timing during zebrafish olfactory neurogenesis

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Fig. 5

Neurog1 and Neurod4 act redundantly during development of zebrafish early-born olfactory neurons. (A-D) Confocal projections of GFP from the Tg(8.4neurog1:GFP) transgene in the olfactory placode of wild-type (A), neurog1 mutant (B), neurod4 morphant (C) and neurog1/neurod4 double loss-of-function (D) embryos at 24 hpf. Abrogation of both Neurod4 and Neurog1 function leads to a severe deficit in the differentiation of early-born olfactory neurons. Placodes are oriented with anterior up. Scale bars: 10 μM. (E) Counts of early-born olfactory neurons per placode at 24 hpf in wild-type, neurog1 mutant, neurod4 morphant, neurog1/neurod4 double loss-of-function embryos and neurog1 mutant embryos in which Neurod4 has been mis-expressed. A minimum of twelve olfactory placode was analysed for each context. Error bars represent s.d. ^*P<0.05, ^**P<0.001, ^***P<0.0005, determined by t-test.

Expression Data

Gene:	GFP
Fish:	sb1Tg sb1Tg + MO1-neurod4 neurog1^{hi1059Tg/hi1059Tg}; sb1Tg neurog1^{hi1059Tg/hi1059Tg}; sb1Tg + MO1-neurod4
Knockdown Reagent:	MO1-neurod4
Anatomical Term:	olfactory placode pioneer neuron
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sb1Tg + MO1-neurod4 neurog1^{hi1059Tg/hi1059Tg}; sb1Tg neurog1^{hi1059Tg/hi1059Tg}; sb1Tg + MO1-neurod4
Knockdown Reagent:	MO1-neurod4
Observed In:	olfactory placode pioneer neuron
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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