FIGURE

Fig. 6

ID

ZDB-FIG-110811-49

Publication

Webb et al., 2011 - The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish

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Fig. 6

her8a expression is independent of endogenous Notch signaling in the early neural plate. Dorsal views of flat-mounted embryos analyzed at the 3-somite stage for the expression of the genes indicated. A-F. Ectopic Notch activation (injection of capped NICD mRNA) abolished neurog1 expression (B) and activates her8a (D) and her4.1 (F) compared to non-injected embryos (ctrl). G-J′. Notch blockade (incubation in the gamma-secretase inhibitor DAPT) increases neurog1 expression within proneural clusters (H) but leaves her8a expression intact (J) at early neural plate stages compared to embryos treated with a vehicle only (ctrl). G′-J′ are high magnification views of the areas boxed in G-J.

Expression Data

Genes:	her4.1 her8a neurog1 tp63
Fish:	WT
Conditions:	chemical treatment: DAPT chemical treatment: pharmaceutical
Anatomical Terms:	midbrain hindbrain boundary neural plate midbrain neural keel midbrain neural keel brain nucleus neural keel non neural ectoderm medial margin presumptive rhombomere 1 presumptive rhombomere 2 presumptive rhombomere 2 lateral region presumptive rhombomere 2 motor neuron
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment: DAPT chemical treatment: pharmaceutical
Observed In:	neurogenesis Notch signaling pathway
Stage:	1-4 somites

Phenotype Detail

Acknowledgments

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