FIGURE

Fig. 3

ID

ZDB-FIG-110214-3

Publication

Radosevic et al., 2011 - Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear

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Fig. 3

Depletion of her9 distorts the development of the SAG but not the generation of hair cells. (A,B) Three-dimensional reconstruction of the SAG at 48 hpf visualized in wild-type and her9-MO-injected zebrafish embryos carrying the islet3:GFP transgene. Arrowheads point to SAG branches. (C,D) Expression of atoh1a in wild-type and Her9 morphant embryos at 24 hpf. (E,F) Sagittal sections of posterior macula showing GFP fluorescence under the control of brn3c (pou4f3) reporter in a wild-type and her9-MO-injected embryo. (G,H) Three-dimensional reconstruction of selected confocal sections showing the otic cristae in wild-type and her9-MO-injected embryos. GFP in adjacent neuromasts of the lateral line has been removed for clarity. C,D, E,F and G,H are at the same magnification. SAG, statoacoustic ganglion; am, anterior macula; ac, anterior crista; lc, lateral crista; pc, posterior crista.

Expression Data

Genes:	atoh1a GFP
Fish:	AB AB + MO2-her9 s356tTg zc7Tg s356tTg + MO2-her9 zc7Tg + MO2-her9
Knockdown Reagent:	MO2-her9
Anatomical Terms:	anterior crista anterior macula lateral crista posterior crista posterior macula statoacoustic (VIII) ganglion
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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