FIGURE

Fig. 1

ID

ZDB-FIG-101118-1

Publication

Chitramuthu et al., 2010 - Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1

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Fig. 1

Zebrafish PGRN-A in situ expression in the Spinal cord and MNs. Lateral view of 24-27 hpf embryos revealed zfPGRN-A expression within the Peripheral and Central Nervous systems. In the head region, zfPGRN-A is expressed at 24 hpf in the head and brain particularly in the tectum, midbrain-hindbrain boundary and eye (Panel A). The sense control displayed minimal signal (Panel B). In addition zfPGRN-A is also expressed at 27 hpf in the somite boundaries (Panel C). At greater magnification of the boxed area in Panel C, zfPGRN-A expression in the somite boundaries is more apparent together with expression in the motoneurons (Panel D). Abbreviations: T: Tectum; E:Eye, MHB:Mid-Brain, Hind-brain Boundary; SB:Somite Boundary, MN:Motoneurons; ICM: Intermediate cell mass. Images were captured at 6X magnification and the hatched box was further subject to 2-3X Zoom

Expression Data

Gene:	grna
Fish:	WT
Anatomical Terms:	CaP motoneuron hindbrain midbrain hindbrain boundary optic cup optic tectum spinal cord motor neuron vertical myoseptum (all 7)
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Neurodegener.