FIGURE

Fig. 7

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ZDB-FIG-100816-19

Publication

Goody et al., 2010 - Nrk2b-mediated NAD+ production regulates cell adhesion and is required for muscle morphogenesis in vivo: Nrk2b and NAD+ in muscle morphogenesis

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Fig. 7

Nrk2b is cell autonomously required for Paxillin localization to MTJs. (A) Cartoon showing dextran labeled wild-type cells being transplanted into a nrk2b morphant host at blastula stage. (B–D) Side mount, anterior left, 26 hpf nrk2b morphant hosts with transplanted wild-type cells (red), β-Dystroglycan antibody staining (light blue, panel B), pY397 FAK antibody staining (dark blue, panel C), and Paxillin antibody staining (green, panel D). Note that β-Dystroglycan and pY397 FAK robustly localize to MTJs in nrk2b morphants in the presence and the absence of transplanted wild-type cells. Note that robust Paxillin localization to the MTJ in nrk2b morphants is rescued in the transplanted wild-type cells, but not in the Nrk2b-deficient cells surrounding them.

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Antibody Labeling

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Acknowledgments

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Reprinted from Developmental Biology, 344(2), Goody, M.F., Kelly, M.W., Lessard, K.N., Khalil, A., and Henry, C.A., Nrk2b-mediated NAD+ production regulates cell adhesion and is required for muscle morphogenesis in vivo: Nrk2b and NAD+ in muscle morphogenesis, 809-826, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.