FIGURE

Fig. 3

ID

ZDB-FIG-100504-56

Publication

Hartnett et al., 2010 - Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos

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Fig. 3

IGF-2 regulates the expression of genes involved in dorsal-ventral patterning. (A,C) Embryos injected with control morpholinos show normal chordin and goosecoid expression. (B,D) Expression of chordin and goosecoid is reduced in IGF-2(a+b) morphant embryos (arrows). (E,G,I) Embryos injected with control morpholinos show normal bmp2b, bmp4 and gata2 expression. (F,H,J) Expression of bmp2b, bmp4 and gata2 is expanded towards the dorsal side in IGF-2(a+b) morphant embryos (asterisks). Frequency of embryos displaying this staining pattern; B, 13/26; D, 17/31; F, 16/25; H, 18/32; J, 26/34. All embryos are shown in a lateral view.

Expression Data

Genes:	bmp2b bmp4 chrd gata2a gsc
Fish:	AB AB + MO1-igf2a + MO3-igf2b
Knockdown Reagents:	MO1-igf2a MO3-igf2b
Anatomical Terms:	ectoderm dorsal region ectoderm ventral region shield whole organism dorsal side whole organism ventral side
Stage Range:	Shield to 75%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-igf2a + MO3-igf2b
Knockdown Reagents:	MO1-igf2a MO3-igf2b
Observed In:	dorsal/ventral pattern formation whole organism
Stage Range:	Shield to 75%-epiboly

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Dev. Biol.