FIGURE

Fig. 6

ID

ZDB-FIG-100422-60

Publication

Schonthaler et al., 2010 - The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness

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Fig. 6

bum^-/- mutant zebrafish survive to adulthood but show smaller eyes lacking a pupil. (A–D) External views of adult sibling (wild-type; wt) and homozygous bum^-/- zebrafish. (A) Lateral views of the left (L) side of the bodies of a female (F) and a male (M) adult sibling zebrafish. (B) Lateral views of the left side of the body of a female and a male homozygous bum^-/- adult zebrafish revealing a bilateral reduction in eye size and a complete lack of a pupil in the mutant. (C, C′) Magnifications of the left (L) and right (R) sides of the head of the female homozygous bum^-/- zebrafish shown in B. (D, D′) Magnifications of the left (L) and right (R) sides of the head of the male homozygous bumper zebrafish shown in B. Note that adult sibling and bum^-/- individuals are of comparable size and, except for the eyes, overall morphology. Scale bars: A, B: 1 cm, C–D′: 2 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bum^tg413/tg413
Observed In:	eye pupil
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 127(3-4), Schonthaler, H.B., Franz-Odendaal, T.A., Hodel, C., Gehring, I., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R., The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness, 203-219, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.