FIGURE

Fig. 3

ID

ZDB-FIG-100128-14

Publication

Schütte et al., 2010 - Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin alpha(2)

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Fig. 3

The vascular system of meprin α₂ knockdown embryos exhibits dramatic defects (B, C).

Microangiography (with TRITC-Dextran) revealed a drastically reduced vascular system without any intersegmental blood vessels (B) in meprin α₂ morphants, compared to the non-injected wild type zebrafish (A). Additionally, erythrocytes accumulated in the ventral caudal tail region (C), possibly as a consequence of this sprouting failure. (PCeV: Posterior cerebral vein; ISV: intersegmental vessels; DLAV: dorsal longitudinal anastomotic vessel; CA: caudal artery; DA: dorsal aorta CV: caudal vein; PCV: posterior cardinal vein; L: liver; H: heart) (Scale bar: 250 μm).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-mep1a.2
Knockdown Reagent:	MO1-mep1a.2
Observed In:	blood circulation intersegmental vessel nucleate erythrocyte post-vent vasculature postero-ventral region vasculature
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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