FIGURE

Fig. 1

ID

ZDB-FIG-091217-82

Publication

den Broeder et al., 2009 - Generation and characterization of FMR1 knockout zebrafish

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Fig. 1

Fmr1 mutant alleles.

A) Illustration of the fmr1 gene product. The different domains are indicated, along with the sites where isolated mutant alleles will affect the protein. B) Whole mount in situ hybridisation with an fmr1 specific probe. C) Immuno staining of wild type and mutant brain sections using Fmr specific antibodies. Some Purkinje cells in the mutant have been outlined. D) Brain lysates were analyzed by western blot, using an Fmr specific antibody. Lanes 1 and 3 contain wild type samples. Lane 2 contains hu2787/hu2787 lysate. Lane 4 contains hu2787/hu2898 lysate. The upper arrow points at Fmr. The lower arrow points at an a-specific band that serves as a loading control.

Expression Data

Gene:	fmr1
Antibody:	Ab1-fmr1
Fish:	WT fmr1^{hu2787/hu2787} (TL) fmr1^hu2787/+; fmr1^hu2898/+ (TL)
Anatomical Terms:	brain Purkinje cell telencephalon neuron
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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