FIGURE

Fig. S4

ID

ZDB-FIG-090306-47

Publication

Matthews et al., 2009 - TNF{alpha}-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

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Fig. S4

5-Azacytidine treatment does not phenocopy dtp liver defects. (A,B) Lateral views of 5-dpf wild-type larvae injected with azacytidine (B) or vehicle (control) at 2, 3 and 4 dpf. (C) Reduced DNA methylation in azacytidine-injected versus control larvae as revealed by anti-methylcytosine (αMeC) slot blot of genomic DNA, with Methylene Blue counterstain (MeBl). (D,E) Comparable liver histology in 5-dpf control and azacytidine-injected larvae. (F) Liver electron micrograph from an azacytidine-injected larva shows normal mitochondrial ultrastructure and no evidence of steatosis. (G) tnfa expression is not elevated in azacytidine-injected larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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