FIGURE

Fig. 5

ID

ZDB-FIG-081117-36

Publication

Nishiwaki et al., 2008 - Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish

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Fig. 5

Ultrastructures of photoreceptors in wild-type and els mutant at adult stage. (A–B) Semi-thin sections of wild-type (A) and the els mutant (B) retinas at 12 mpf. In the outer photoreceptor layer, the regions consisting of rod OS, cone cells and rod nuclei can be distinguished. In the els mutant retina, the region where cone cells are normally located appears to be replaced with the region consisting of the OS of rods, suggesting that cone cells are specifically eliminated in the els mutant. RGCL, RGC layer. (C) OS and ellipsoid (e) of rods in wild-type. Connecting cilia are observed (arrowhead). (D) OS and ellipsoid (e) of cones in wild-type. (E) OPL in wild-type. Dense-stained structures representing synaptic ribbons (arrowhead) are observed underneath rod nuclei (n) in the OPL. (F) OS and ellipsoid (e) of rods in the els mutant. These structures are normal. (G) Connecting cilia of rods in the els mutant. (H) OPL in the els mutant. Nuclei of rods (n (rod)) and horizontal cells (n (ho)) are shown at the upper left and bottom right corners of this image, respectively.

Expression Data

Antibody:	Ab3-BrdU
Fish:	WT pde6c^rw76a/rw76a
Anatomical Terms:	ciliary marginal zone retinal inner nuclear layer retinal outer nuclear layer
Stage:	Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pde6c^rw76a/rw76a
Observed In:	retinal cone cell retinal inner nuclear layer cell
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 125(11-12), Nishiwaki, Y., Komori, A., Sagara, H., Suzuki, E., Manabe, T., Hosoya, T., Nojima, Y., Wada, H., Tanaka, H., Okamoto, H., and Masai, I., Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish, 932-946, Copyright (2008) with permission from Elsevier. Full text @ Mech. Dev.