FIGURE

Fig. 7

ID

ZDB-FIG-080908-12

Publication

Clay et al., 2008 - Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Increased Cording Seen in the Absence of TNF Signaling Is Not Dependent on the RD1 Virulence Locus or Granuloma Formation

(A) Control (n = 23) and TR1 morphant (n = 9) embryos were infected with 353 ± 10 ΔRD1 bacteria and scored daily for the presence of extracellular bacteria as indicated by cording and plotted as the percentage of embryos with cording. A significantly greater percentage of TR1 morphant embryos display cording versus control embryos at 5 dpi (p < 0.01) and 6 dpi (p < 0.05) as analyzed by Fisher's exact test of a contingency table. (B) and (C) show examples of cording found during infection of TR1 morphant embryos infected with ΔRD1 at 6 dpi. The scale bar represents 25 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WIK + MO1-tnfrsf1a + MO2-tnfrsf1a
Condition:	bacterial treatment: Mycobacterium marinum
Knockdown Reagents:	MO1-tnfrsf1a MO2-tnfrsf1a
Observed In:	defense response to bacterium
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Immunity, 29(2), Clay, H., Volkman, H.E., and Ramakrishnan, L., Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death, 283-294, Copyright (2008) with permission from Elsevier. Full text @ Immunity