FIGURE

Fig. 6

ID

ZDB-FIG-080730-19

Publication

Clément et al., 2008 - Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher

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Fig. 6

Condensation morphogenesis is absent in dak^-/- larvae.

Pre-cartilage condensations in the first arch are larger in dak^-/- larvae as judged by sox9a staining at 45hpf (A,B) and 50hpf (C,D). Individual cells within the condensation appear to have a more rounded morphology in dak^-/- larvae than in wild-type larvae (compare arrows in C,D). Intercalation and flattening of chondrocytes to give rise to the ceratohyal cartilage in the second arch takes place between 54 and 58hpf in wild-type (E,G), but does not occur in dak^-/- larvae (F,H). Chondrocytes begin to secrete cartilage matrix during this time as seen by Alcian Blue staining (G,H). Camera lucida drawings of chondrocytes in wild-type and dak^-/- larvae (E′–H′). Scale bars = 10μM.

Expression Data

Gene:	sox9a
Fish:	WT ext2^{to273b/to273b}
Anatomical Terms:	chondrocyte mandibular arch skeleton
Stage Range:	High-pec to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ext2^{to273b/to273b}
Observed In:	cartilage development chondrocyte
Stage Range:	High-pec to Long-pec

Phenotype Detail

Acknowledgments

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